5K14
HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog
5K14 の概要
エントリーDOI | 10.2210/pdb5k14/pdb |
分子名称 | HIV-1 reverse transcriptase(isolate HXB2), HIV-1 reverse transcriptase (isolate LW123), 4-{[4-(2,6-difluoro-4-methoxybenzene-1-carbonyl)pyrimidin-2-yl]amino}benzonitrile, ... (4 entities in total) |
機能のキーワード | hiv-1, reverse transcriptase, nnrti, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) 詳細 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P0C6F2 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 116328.32 |
構造登録者 | |
主引用文献 | Simon, P.,Baszczynski, O.,Saman, D.,Stepan, G.,Hu, E.,Lansdon, E.B.,Jansa, P.,Janeba, Z. Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1. Eur.J.Med.Chem., 122:185-195, 2016 Cited by PubMed: 27371922DOI: 10.1016/j.ejmech.2016.06.026 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.402 Å) |
構造検証レポート
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