5K13

Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist

5K13 の概要

• エントリーDOI: 10.2210/pdb5k13/pdb
• 分子名称: Retinoic acid receptor alpha, 4-{5-(3-tert-butylphenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}benzoic acid (3 entities in total)
• 機能のキーワード: nhr ligand-binding domain, antagonist, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P10276
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28163.69

構造登録者

Wang, Y.,Stout, S.L. (登録日: 2016-05-17, 公開日: 2016-06-22, 最終更新日: 2023-09-27)

• 主引用文献: Hughes, N.E.,Bleisch, T.J.,Jones, S.A.,Richardson, T.I.,Doti, R.A.,Wang, Y.,Stout, S.L.,Durst, G.L.,Chambers, M.G.,Oskins, J.L.,Lin, C.,Adams, L.A.,Page, T.J.,Barr, R.J.,Zink, R.W.,Osborne, H.,Montrose-Rafizadeh, C.,Norman, B.H.; Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design.; Bioorg.Med.Chem.Lett., 26:3274-3277, 2016; PubMed: 27261179; DOI: 10.1016/j.bmcl.2016.05.056

実験手法

X-RAY DIFFRACTION (1.85 Å)