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5K0X

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541

5K0X の概要
エントリーDOI10.2210/pdb5k0x/pdb
関連するPDBエントリー5K0K
分子名称Tyrosine-protein kinase Mer, CHLORIDE ION, (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide, ... (4 entities in total)
機能のキーワードmacrocyclic, drug design, fibrinolytic agents, protein kinase inhibitors, proto-oncogene proteins, pyrimidines, receptor protein-tyrosine kinases, structure-activity relationship, thrombosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Homo sapiens (Human)
細胞内の位置Membrane ; Single-pass type I membrane protein : Q12866
タンパク質・核酸の鎖数2
化学式量合計72899.28
構造登録者
主引用文献McIver, A.L.,Zhang, W.,Liu, Q.,Jiang, X.,Stashko, M.A.,Nichols, J.,Miley, M.J.,Norris-Drouin, J.,Machius, M.,DeRyckere, D.,Wood, E.,Graham, D.K.,Earp, H.S.,Kireev, D.,Frye, S.V.,Wang, X.
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem, 12:207-213, 2017
Cited by
PubMed: 28032464
DOI: 10.1002/cmdc.201600589
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.231 Å)
構造検証レポート
Validation report summary of 5k0x
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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