5K0K

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434

5K0K の概要

• エントリーDOI: 10.2210/pdb5k0k/pdb
• 関連するPDBエントリー: 5K0X
• 分子名称: Tyrosine-protein kinase Mer, CHLORIDE ION, 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]te traazacyclotetradecin-8(3H)-one, ... (5 entities in total)
• 機能のキーワード: macrocyclic, pyrrolopyrimidines, drug design, fibrinolytic agents, protein kinase inhibitors, proto-oncogene proteins, pyrimidines, receptor protein-tyrosine kinases, structure-activity relationship, thrombosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane ; Single-pass type I membrane protein : Q12866
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72939.09

構造登録者

Wang, X.,Liu, J.,Zhang, W.,Stashko, M.A.,Nichols, J.,DeRyckere, D.,Miley, M.J.,Norris-Drouin, J.,Chen, Z.,Machius, M.,Wood, E.,Graham, D.K.,Earp, H.S.,Graham, K.,Kireev, D.,Frye, S.V. (登録日: 2016-05-17, 公開日: 2017-01-11, 最終更新日: 2023-09-27)

• 主引用文献: Wang, X.,Liu, J.,Zhang, W.,Stashko, M.A.,Nichols, J.,Miley, M.J.,Norris-Drouin, J.,Chen, Z.,Machius, M.,DeRyckere, D.,Wood, E.,Graham, D.K.,Earp, H.S.,Kireev, D.,Frye, S.V.; Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.; ACS Med Chem Lett, 7:1044-1049, 2016; PubMed: 27994735; DOI: 10.1021/acsmedchemlett.6b00221

実験手法

X-RAY DIFFRACTION (2.545 Å)