5JZN

Crystal structure of DCLK1-KD in complex with NVP-TAE684

Summary for 5JZN

• Entry DOI: 10.2210/pdb5jzn/pdb
• Related: 5JZJ
• Descriptor: Serine/threonine-protein kinase DCLK1, 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, doublecortin, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 63923.96

Authors

Patel, O.,Lucet, I. (deposition date: 2016-05-17, release date: 2016-08-24, Last modification date: 2023-09-27)

• Primary citation: Patel, O.,Dai, W.,Mentzel, M.,Griffin, M.D.,Serindoux, J.,Gay, Y.,Fischer, S.,Sterle, S.,Kropp, A.,Burns, C.J.,Ernst, M.,Buchert, M.,Lucet, I.S.; Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.; Structure, 24:1550-1561, 2016; PubMed: 27545623; DOI: 10.1016/j.str.2016.07.008

Experimental method

X-RAY DIFFRACTION (2.85 Å)