5JYY

Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses

Replaces:  5E6L

Summary for 5JYY

• Entry DOI: 10.2210/pdb5jyy/pdb
• Related: 4MWX
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: neuraminidase inhibitor, tetravalent zanamivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Total number of polymer chains: 1
• Total formula weight: 46000.79

Authors

Fu, L.,Wu, Y.,Bi, Y.,Zhang, S.,Lv, X.,Qi, J.,Li, Y.,Lu, X.,Yan, J.,Gao, G.F.,Li, X. (deposition date: 2016-05-15, release date: 2016-06-29, Last modification date: 2023-11-08)

• Primary citation: Fu, L.,Bi, Y.,Wu, Y.,Zhang, S.,Qi, J.,Li, Y.,Lu, X.,Zhang, Z.,Lv, X.,Yan, J.,Gao, G.F.,Li, X.; Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses; J.Med.Chem., 59:6303-6312, 2016; PubMed: 27341624; DOI: 10.1021/acs.jmedchem.6b00537

Experimental method

X-RAY DIFFRACTION (2.1 Å)