5JYY

Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses

「5E6L」から置き換えられました

5JYY の概要

• エントリーDOI: 10.2210/pdb5jyy/pdb
• 関連するPDBエントリー: 4MWX
• 分子名称: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: neuraminidase inhibitor, tetravalent zanamivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46000.79

構造登録者

Fu, L.,Wu, Y.,Bi, Y.,Zhang, S.,Lv, X.,Qi, J.,Li, Y.,Lu, X.,Yan, J.,Gao, G.F.,Li, X. (登録日: 2016-05-15, 公開日: 2016-06-29, 最終更新日: 2023-11-08)

• 主引用文献: Fu, L.,Bi, Y.,Wu, Y.,Zhang, S.,Qi, J.,Li, Y.,Lu, X.,Zhang, Z.,Lv, X.,Yan, J.,Gao, G.F.,Li, X.; Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses; J.Med.Chem., 59:6303-6312, 2016; PubMed: 27341624; DOI: 10.1021/acs.jmedchem.6b00537

実験手法

X-RAY DIFFRACTION (2.1 Å)