5JYC
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate
Summary for 5JYC
Entry DOI | 10.2210/pdb5jyc/pdb |
Descriptor | CFTR inhibitory factor, (5~{Z},11~{Z},14~{R},15~{R})-14,15-bis(oxidanyl)icosa-5,8,11-trienoic acid (3 entities in total) |
Functional Keywords | epoxide hydrolase, hydroxyalkyl-enzyme intermediate, hydrolase |
Biological source | Pseudomonas aeruginosa (strain UCBPP-PA14) |
Total number of polymer chains | 4 |
Total formula weight | 138008.79 |
Authors | Hvorecny, K.L.,Madden, D.R. (deposition date: 2016-05-13, release date: 2017-01-11, Last modification date: 2023-09-27) |
Primary citation | Flitter, B.A.,Hvorecny, K.L.,Ono, E.,Eddens, T.,Yang, J.,Kwak, D.H.,Bahl, C.D.,Hampton, T.H.,Morisseau, C.,Hammock, B.D.,Liu, X.,Lee, J.S.,Kolls, J.K.,Levy, B.D.,Madden, D.R.,Bomberger, J.M. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc. Natl. Acad. Sci. U.S.A., 114:136-141, 2017 Cited by PubMed: 27980032DOI: 10.1073/pnas.1610242114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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