5JXS

Mutant GC216/7AA of 3D polymerase from Foot-and-Mouth Disease Virus

Summary for 5JXS

• Entry DOI: 10.2210/pdb5jxs/pdb
• Descriptor: RNA dependent RNA polymerase, RNA Template, RNA Primer, ... (5 entities in total)
• Functional Keywords: rna-dependent rna polymerase picornavirus foot and mouth disease virus, transferase
• Biological source: Foot-and-mouth disease virus (FMDV); More
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03311
• Total number of polymer chains: 3
• Total formula weight: 58564.39

Authors

Verdaguer, N.,Ferrer-Orta, C. (deposition date: 2016-05-13, release date: 2016-06-01, Last modification date: 2024-01-10)

• Primary citation: Herod, M.R.,Ferrer-Orta, C.,Loundras, E.A.,Ward, J.C.,Verdaguer, N.,Rowlands, D.J.,Stonehouse, N.J.; Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.; J.Virol., 90:6864-6883, 2016; PubMed: 27194768; DOI: 10.1128/JVI.00469-16

Experimental method

X-RAY DIFFRACTION (2.8 Å)