5JXJ

Structure of the proprotein convertase furin complexed to meta-guanidinomethyl-Phac-RVR-Amba in presence of EDTA

Summary for 5JXJ

• Entry DOI: 10.2210/pdb5jxj/pdb
• Related PRD ID: PRD_001220
• Descriptor: Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: protease, inhibitor, proteolysis, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
• Total number of polymer chains: 2
• Total formula weight: 53338.00

Authors

Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. (deposition date: 2016-05-13, release date: 2016-10-05, Last modification date: 2024-01-10)

• Primary citation: Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E.; Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.; Proc.Natl.Acad.Sci.USA, 113:11196-11201, 2016; PubMed: 27647913; DOI: 10.1073/pnas.1613630113

Experimental method

X-RAY DIFFRACTION (2 Å)