5JXJ
Structure of the proprotein convertase furin complexed to meta-guanidinomethyl-Phac-RVR-Amba in presence of EDTA
Summary for 5JXJ
Entry DOI | 10.2210/pdb5jxj/pdb |
Related PRD ID | PRD_001220 |
Descriptor | Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | protease, inhibitor, proteolysis, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958 |
Total number of polymer chains | 2 |
Total formula weight | 53354.00 |
Authors | Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. (deposition date: 2016-05-13, release date: 2016-10-05, Last modification date: 2024-07-10) |
Primary citation | Dahms, S.O.,Arciniega, M.,Steinmetzer, T.,Huber, R.,Than, M.E. Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc.Natl.Acad.Sci.USA, 113:11196-11201, 2016 Cited by PubMed: 27647913DOI: 10.1073/pnas.1613630113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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