5JW2

Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGATCCCT

Summary for 5JW2

• Entry DOI: 10.2210/pdb5jw2/pdb
• Descriptor: DNA (5'-D(*AP*GP*GP*GP*AP*TP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ZINC ION, ... (4 entities in total)
• Functional Keywords: anti-cancer agent, dna binding, natural product, transcription factor, ewing sarcoma, dna-antibiotic complex, dna/antibiotic
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 11170.12

Authors

Hou, C.,Rohr, J.,Tsodikov, O.V. (deposition date: 2016-05-11, release date: 2016-09-14, Last modification date: 2024-03-06)

• Primary citation: Hou, C.,Weidenbach, S.,Cano, K.E.,Wang, Z.,Mitra, P.,Ivanov, D.N.,Rohr, J.,Tsodikov, O.V.; Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.; Nucleic Acids Res., 44:8990-9004, 2016; PubMed: 27587584; DOI: 10.1093/nar/gkw761

Experimental method

X-RAY DIFFRACTION (3.1 Å)