5JW0
Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT
Summary for 5JW0
Entry DOI | 10.2210/pdb5jw0/pdb |
Related | 5JVT 5JVW 5JW2 |
Descriptor | DNA (5'-D(P*AP*GP*GP*GP*TP*AP*CP*CP*CP*T)-3'), Plicamycin, mithramycin analogue MTM SA-Phe, ZINC ION, ... (4 entities in total) |
Functional Keywords | anti-cancer agent, dna binding, natural product, transcription factor, ewing sarcoma, dna-antibiotic complex, dna/antibiotic |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 11235.53 |
Authors | Hou, C.,Rohr, J.,Tsodikov, O.V. (deposition date: 2016-05-11, release date: 2016-09-14, Last modification date: 2024-03-06) |
Primary citation | Hou, C.,Weidenbach, S.,Cano, K.E.,Wang, Z.,Mitra, P.,Ivanov, D.N.,Rohr, J.,Tsodikov, O.V. Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1. Nucleic Acids Res., 44:8990-9004, 2016 Cited by PubMed: 27587584DOI: 10.1093/nar/gkw761 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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