5JVY

Crystal structure of S121P murine COX-2 mutant

5JVY の概要

• エントリーDOI: 10.2210/pdb5jvy/pdb
• 関連するPDBエントリー: 5JVZ 5JW1
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: cyclooxygenase, cox, nsaid, oxidoreductase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130396.11

構造登録者

Orlando, B.J.,Malkowski, M.G.,Dong, L. (登録日: 2016-05-11, 公開日: 2016-10-26, 最終更新日: 2023-09-27)

• 主引用文献: Dong, L.,Yuan, C.,Orlando, B.J.,Malkowski, M.G.,Smith, W.L.; Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.; J.Biol.Chem., 291:25641-25655, 2016; PubMed: 27756840; DOI: 10.1074/jbc.M116.757310

実験手法

X-RAY DIFFRACTION (2.36 Å)