5JVX

X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene compound

5JVX の概要

• エントリーDOI: 10.2210/pdb5jvx/pdb
• 分子名称: Thaumatin-1, L(+)-TARTARIC ACID, (1-butyl-3-methyl-1,3-dihydro-2H-imidazol-2-ylidene)(chloro)gold, ... (5 entities in total)
• 機能のキーワード: plant protein
• 由来する生物種: Thaumatococcus daniellii (Katemfe)
• 細胞内の位置: Cytoplasmic vesicle: P02883
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24786.47

構造登録者

Ferraro, G.,Merlino, A. (登録日: 2016-05-11, 公開日: 2016-07-13, 最終更新日: 2024-10-16)

主引用文献

Ferraro, G.,Gabbiani, C.,Merlino, A.
First Crystal Structure for a Gold Carbene-Protein Adduct.
Bioconjug.Chem., 27:1584-1587, 2016

PubMed Abstract: The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)(+) fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl(-) ligand, but retaining NHC fragment.

PubMed: 27364343
DOI: 10.1021/acs.bioconjchem.6b00298

実験手法

X-RAY DIFFRACTION (1.7 Å)