5JUZ

Crystal structure of human FPPS in complex with an allosteric inhibitor CL-06-057

Summary for 5JUZ

Entry DOI	10.2210/pdb5juz/pdb
Related	5JV0 5JV1 5JV2
Descriptor	Farnesyl pyrophosphate synthase, CHLORIDE ION, [(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid, ... (4 entities in total)
Functional Keywords	transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43669.34
Authors	Park, J.,Magder, A.,Leung, C.Y.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2016-05-10, release date: 2017-03-15, Last modification date: 2023-09-27)
Primary citation	Park, J.,Leung, C.Y.,Matralis, A.N.,Lacbay, C.M.,Tsakos, M.,Fernandez De Troconiz, G.,Berghuis, A.M.,Tsantrizos, Y.S. Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60:2119-2134, 2017 Cited by PubMed: 28208018 DOI: 10.1021/acs.jmedchem.6b01888 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation