5JS9

Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128

5JS9 の概要

• エントリーDOI: 10.2210/pdb5js9/pdb
• 関連するPDBエントリー: 5JSA
• 分子名称: broadly neutralizing antibody PGT128 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• 機能のキーワード: hiv-1 trimer, ufo, sosip, vaccine, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 179396.61

構造登録者

Kong, L.,Wilson, I.A. (登録日: 2016-05-07, 公開日: 2016-07-13, 最終更新日: 2023-09-27)

• 主引用文献: Kong, L.,He, L.,de Val, N.,Vora, N.,Morris, C.D.,Azadnia, P.,Sok, D.,Zhou, B.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Zhu, J.; Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.; Nat Commun, 7:12040-12040, 2016; PubMed: 27349805; DOI: 10.1038/ncomms12040

実験手法

X-RAY DIFFRACTION (6.918 Å)