5JOG

CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-3

5JOG の概要

• エントリーDOI: 10.2210/pdb5jog/pdb
• 分子名称: COP9 signalosome complex subunit 5, ZINC ION, 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide, ... (4 entities in total)
• 機能のキーワード: cop9 signalosome, metal protease, inhibitor, hydroxylase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q92905
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29521.95

構造登録者

Renatus, M.,Wiesmann, C. (登録日: 2016-05-02, 公開日: 2016-11-02, 最終更新日: 2024-01-10)

• 主引用文献: Schlierf, A.,Altmann, E.,Quancard, J.,Jefferson, A.B.,Assenberg, R.,Renatus, M.,Jones, M.,Hassiepen, U.,Schaefer, M.,Kiffe, M.,Weiss, A.,Wiesmann, C.,Sedrani, R.,Eder, J.,Martoglio, B.; Targeted inhibition of the COP9 signalosome for treatment of cancer.; Nat Commun, 7:13166-13166, 2016; PubMed: 27774986; DOI: 10.1038/ncomms13166

実験手法

X-RAY DIFFRACTION (2.46 Å)