5JM4

Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain

Summary for 5JM4

• Entry DOI: 10.2210/pdb5jm4/pdb
• Related: 4N7G 4N84
• Descriptor: 14-3-3 protein zeta/delta, GLN-GLY-MKD-ANG-ASP-MKD-LEU-ASP-LEU-ALA-CLU, BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: peptidomimetic, ppi inhibitor, macrocycle, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 55687.07

Authors

Bier, D.,Krueger, D.,Glas, A.,Wallraven, K.,Ottmann, C.,Hennig, S.,Grossmann, T. (deposition date: 2016-04-28, release date: 2017-05-10, Last modification date: 2024-01-10)

• Primary citation: Kruger, D.M.,Glas, A.,Bier, D.,Pospiech, N.,Wallraven, K.,Dietrich, L.,Ottmann, C.,Koch, O.,Hennig, S.,Grossmann, T.N.; Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.; J. Med. Chem., 60:8982-8988, 2017; PubMed: 29028171; DOI: 10.1021/acs.jmedchem.7b01221

Experimental method

X-RAY DIFFRACTION (2.34 Å)