5JLG

The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and compound I, a piano-stool organometallic Ru(II) arene compound containing an O,S-chelating ligand

Summary for 5JLG

Entry DOI	10.2210/pdb5jlg/pdb
Descriptor	Ribonuclease pancreatic, RUTHENIUM ION, methyl (2Z)-3-hydroxy-3-(3-hydroxyphenyl)prop-2-ene(dithioate), ... (5 entities in total)
Functional Keywords	ruthenated protein, protein-ru compound adducts, hydrolase, piano-stool organometallic ru(ii) arene compounds
Biological source	Bos taurus (Cattle)
Cellular location	Secreted: P61823
Total number of polymer chains	2
Total formula weight	28305.82
Authors	Ferraro, G.,Merlino, A. (deposition date: 2016-04-27, release date: 2016-08-03, Last modification date: 2024-01-10)
Primary citation	Hildebrandt, J.,Gorls, H.,Hafner, N.,Ferraro, G.,Durst, M.,Runnebaum, I.B.,Weigand, W.,Merlino, A. Unusual mode of protein binding by a cytotoxic pi-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand. Dalton Trans, 45:12283-12287, 2016 Cited by PubMed: 27427335 DOI: 10.1039/c6dt02380k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation