5JLC

Structure of CYP51 from the pathogen Candida glabrata

Summary for 5JLC

Entry DOI	10.2210/pdb5jlc/pdb
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (7 entities in total)
Functional Keywords	pathogen, candida glabrata, cyp51, itraconazole, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreducatse inhibitor
Biological source	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast)
Total number of polymer chains	1
Total formula weight	61109.33
Authors	Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2016-04-26, release date: 2016-05-25, Last modification date: 2023-09-27)
Primary citation	Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Woods, M.A.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C. Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery. Antimicrob.Agents Chemother., 62:-, 2018 Cited by PubMed: 30126961 DOI: 10.1128/AAC.01134-18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation