5JLC

Structure of CYP51 from the pathogen Candida glabrata

5JLC の概要

• エントリーDOI: 10.2210/pdb5jlc/pdb
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (7 entities in total)
• 機能のキーワード: pathogen, candida glabrata, cyp51, itraconazole, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreducatse inhibitor
• 由来する生物種: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61109.33

構造登録者

Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C. (登録日: 2016-04-26, 公開日: 2016-05-25, 最終更新日: 2023-09-27)

• 主引用文献: Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Woods, M.A.,Sagatova, A.A.,Tyndall, J.D.A.,Monk, B.C.; Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.; Antimicrob.Agents Chemother., 62:-, 2018; PubMed: 30126961; DOI: 10.1128/AAC.01134-18

実験手法

X-RAY DIFFRACTION (2.4 Å)