5JJS

Dengue 3 NS5 protein with compound 27

Summary for 5JJS

• Entry DOI: 10.2210/pdb5jjs/pdb
• Related: 5JJR
• Descriptor: Genome polyprotein, ZINC ION, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
• Functional Keywords: rdrp, dengue, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Dengue virus 3
• Cellular location: Virion membrane ; Multi-pass membrane protein : Q6DLV0
• Total number of polymer chains: 1
• Total formula weight: 104846.85

Authors

Lescar, J.,El Sahili, A. (deposition date: 2016-04-25, release date: 2016-07-06, Last modification date: 2023-11-08)

• Primary citation: Lim, S.P.,Noble, C.G.,Seh, C.C.,Soh, T.S.,El Sahili, A.,Chan, G.K.,Lescar, J.,Arora, R.,Benson, T.,Nilar, S.,Manjunatha, U.,Wan, K.F.,Dong, H.,Xie, X.,Shi, P.Y.,Yokokawa, F.; Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling; Plos Pathog., 12:e1005737-e1005737, 2016; PubMed: 27500641; DOI: 10.1371/journal.ppat.1005737

Experimental method

X-RAY DIFFRACTION (1.65 Å)