5JII

Crystal structure of human IgG1-Fc

Summary for 5JII

• Entry DOI: 10.2210/pdb5jii/pdb
• Related: 5JIH 5JIK
• Descriptor: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: immune system, antibody, immunoglobulin g1, fc fragment, glycosylations
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : P01857
• Total number of polymer chains: 2
• Total formula weight: 52939.05

Authors

Humm, A.,Lobner, E.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2016-04-22, release date: 2017-04-12, Last modification date: 2024-01-10)

• Primary citation: Lobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.; Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.; Structure, 25:878-889.e5, 2017; PubMed: 28528777; DOI: 10.1016/j.str.2017.04.014

Experimental method

X-RAY DIFFRACTION (1.79 Å)