5JIC

Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog

5JIC の概要

• エントリーDOI: 10.2210/pdb5jic/pdb
• 分子名称: Type II pantothenate kinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: pantothenamide, inhibitor, antimicrobial, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Staphylococcus aureus (strain MW2)
• 細胞内の位置: Cytoplasm : Q8NVG0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30805.71

構造登録者

Hughes, S.J.,Antoshchenko, T.,Mottaghi, K.,Barnard, L.,Strauss, E.,Park, H. (登録日: 2016-04-22, 公開日: 2016-08-10, 最終更新日: 2023-09-27)

• 主引用文献: Hughes, S.J.,Barnard, L.,Mottaghi, K.,Tempel, W.,Antoshchenko, T.,Hong, B.S.,Allali-Hassani, A.,Smil, D.,Vedadi, M.,Strauss, E.,Park, H.W.; Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.; Acs Infect Dis., 2:627-641, 2016; PubMed: 27759386; DOI: 10.1021/acsinfecdis.6b00090

実験手法

X-RAY DIFFRACTION (1.4 Å)