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5JI6

Potent, Reversible MetAP2 Inhibitors via FBDD

Summary for 5JI6
Entry DOI10.2210/pdb5ji6/pdb
Related5JFR 5JHU
DescriptorMethionine aminopeptidase 2, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total)
Functional Keywordshydrolase, peptidase, metal ion binding, proteolysis, hydrolase4-hydrolase inhibitor complex, hydrolase4/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P50579
Total number of polymer chains1
Total formula weight41839.16
Authors
Dougan, D.R.,Lawson, J.D. (deposition date: 2016-04-21, release date: 2016-05-25, Last modification date: 2017-11-22)
Primary citationCheruvallath, Z.,Tang, M.,McBride, C.,Komandla, M.,Miura, J.,Ton-Nu, T.,Erikson, P.,Feng, J.,Farrell, P.,Lawson, J.D.,Vanderpool, D.,Wu, Y.,Dougan, D.R.,Plonowski, A.,Holub, C.,Larson, C.
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1.
Bioorg.Med.Chem.Lett., 26:2774-2778, 2016
Cited by
PubMed: 27155900
DOI: 10.1016/j.bmcl.2016.04.073
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

217705

건을2024-03-27부터공개중

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