5JGS

Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide

Summary for 5JGS

Entry DOI	10.2210/pdb5jgs/pdb
Descriptor	Carbonic anhydrase 2, 1,3-benzothiazole-2-sulfonamide, ZINC ION, ... (4 entities in total)
Functional Keywords	anhydrase, mutant, water, hydrophobic, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29400.50
Authors	Fox, J.M.,Kang, K.,Sastry, M.,Sherman, W.,Sankaran, B.,Zwart, P.H.,Whitesides, G.M. (deposition date: 2016-04-20, release date: 2017-01-11, Last modification date: 2023-09-27)
Primary citation	Fox, J.M.,Kang, K.,Sastry, M.,Sherman, W.,Sankaran, B.,Zwart, P.H.,Whitesides, G.M. Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase. Angew. Chem. Int. Ed. Engl., 56:3833-3837, 2017 Cited by PubMed: 28252841 DOI: 10.1002/anie.201609409 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.11 Å)

Structure validation