5JFX

Crystal structure of TrkA in complex with PF-06273340

5JFX の概要

• エントリーDOI: 10.2210/pdb5jfx/pdb
• 関連するPDBエントリー: 5JFS 5JFV 5JFW
• 分子名称: High affinity nerve growth factor receptor, N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide (3 entities in total)
• 機能のキーワード: trka inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P04629
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35581.47

構造登録者

Jayasankar, J.,Kurumbail, R.,Skerratt, S.,Brown, D. (登録日: 2016-04-19, 公開日: 2017-03-01, 最終更新日: 2024-03-06)

• 主引用文献: Skerratt, S.E.,Andrews, M.,Bagal, S.K.,Bilsland, J.,Brown, D.,Bungay, P.J.,Cole, S.,Gibson, K.R.,Jones, R.,Morao, I.,Nedderman, A.,Omoto, K.,Robinson, C.,Ryckmans, T.,Skinner, K.,Stupple, P.,Waldron, G.; The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.; J. Med. Chem., 59:10084-10099, 2016; PubMed: 27766865; DOI: 10.1021/acs.jmedchem.6b00850

実験手法

X-RAY DIFFRACTION (1.63 Å)