5JDU

Crystal structure for human thrombin mutant D189A

Summary for 5JDU

• Entry DOI: 10.2210/pdb5jdu/pdb
• Related: 1SHH
• Descriptor: Thrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: serine protease, coagulation, conformational equilibrium, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 68031.18

Authors

Pozzi, N.,Chen, Z.,Di Cera, E. (deposition date: 2016-04-17, release date: 2016-07-13, Last modification date: 2023-09-27)

• Primary citation: Pozzi, N.,Zerbetto, M.,Acquasaliente, L.,Tescari, S.,Frezzato, D.,Polimeno, A.,Gohara, D.W.,Di Cera, E.,De Filippis, V.; Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin.; Biochemistry, 55:3984-3994, 2016; PubMed: 27347732; DOI: 10.1021/acs.biochem.6b00385

Experimental method

X-RAY DIFFRACTION (1.7 Å)