5JCT

Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24

5JCT の概要

• エントリーDOI: 10.2210/pdb5jct/pdb
• 分子名称: Pirin, FE (III) ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: cupin, beta-barrel fold, inhibitor, complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : O00625
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35185.60

構造登録者

Ali, S.,van Montfort, R. (登録日: 2016-04-15, 公開日: 2017-01-11, 最終更新日: 2024-01-10)

• 主引用文献: Cheeseman, M.D.,Chessum, N.E.,Rye, C.S.,Pasqua, A.E.,Tucker, M.J.,Wilding, B.,Evans, L.E.,Lepri, S.,Richards, M.,Sharp, S.Y.,Ali, S.,Rowlands, M.,O'Fee, L.,Miah, A.,Hayes, A.,Henley, A.T.,Powers, M.,Te Poele, R.,De Billy, E.,Pellegrino, L.,Raynaud, F.,Burke, R.,van Montfort, R.L.,Eccles, S.A.,Workman, P.,Jones, K.; Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.; J. Med. Chem., 60:180-201, 2017; PubMed: 28004573; DOI: 10.1021/acs.jmedchem.6b01055

実験手法

X-RAY DIFFRACTION (1.73 Å)