5JC3

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).

5JC3 の概要

• エントリーDOI: 10.2210/pdb5jc3/pdb
• 分子名称: Melanoma differentiation associated protein-5, RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3'), ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: innate immune pattern recognition receptor, rig-i like helicase, dsrna dependent atpase, zinc-containing ctd domain, immune system
• 由来する生物種: Gallus gallus (Chicken); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 177075.64

構造登録者

Cusack, S.,Uchikawa, E. (登録日: 2016-04-14, 公開日: 2016-06-01, 最終更新日: 2024-01-10)

• 主引用文献: Uchikawa, E.,Lethier, M.,Malet, H.,Brunel, J.,Gerlier, D.,Cusack, S.; Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.; Mol.Cell, 62:586-602, 2016; PubMed: 27203181; DOI: 10.1016/j.molcel.2016.04.021

実験手法

X-RAY DIFFRACTION (2.6 Å)