5J9F
Human GAR transformylase in complex with GAR and (4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic acid (AGF183)
Summary for 5J9F
Entry DOI | 10.2210/pdb5j9f/pdb |
Related | 5IZQ |
Descriptor | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | gar transformylase, antifolate, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 23479.67 |
Authors | Wong, J.,Deis, S.M.,Dann III, C.E. (deposition date: 2016-04-09, release date: 2016-08-10, Last modification date: 2023-09-27) |
Primary citation | Golani, L.K.,Wallace-Povirk, A.,Deis, S.M.,Wong, J.,Ke, J.,Gu, X.,Raghavan, S.,Wilson, M.R.,Li, X.,Polin, L.,de Waal, P.W.,White, K.,Kushner, J.,O'Connor, C.,Hou, Z.,Xu, H.E.,Melcher, K.,Dann, C.E.,Matherly, L.H.,Gangjee, A. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59:7856-7876, 2016 Cited by PubMed: 27458733DOI: 10.1021/acs.jmedchem.6b00594 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report