5J89
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
Summary for 5J89
Entry DOI | 10.2210/pdb5j89/pdb |
Descriptor | Programmed cell death 1 ligand 1, N-{2-[({2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | pd-l1, programmed cell death 1 ligand 1, cell cycle, immune system |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7 |
Total number of polymer chains | 4 |
Total formula weight | 67838.12 |
Authors | Zak, K.M.,Grudnik, P.,Guzik, K.,Zieba, B.J.,Musielak, B.,Doemling, P.,Dubin, G.,Holak, T.A. (deposition date: 2016-04-07, release date: 2016-04-27, Last modification date: 2024-01-10) |
Primary citation | Zak, K.M.,Grudnik, P.,Guzik, K.,Zieba, B.J.,Musielak, B.,Domling, A.,Dubin, G.,Holak, T.A. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget, 7:30323-30335, 2016 Cited by PubMed: 27083005DOI: 10.18632/oncotarget.8730 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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