5J7G

Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.

5J7G の概要

• エントリーDOI: 10.2210/pdb5j7g/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid (3 entities in total)
• 機能のキーワード: p53, mdm2, mdmx, protein-protein interaction, cancer, inhibitor, ligase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 53036.13

構造登録者

Twarda-Clapa, A.,Kubica, K.,Guzik, K.,Dubin, G.,Holak, T.A. (登録日: 2016-04-06, 公開日: 2017-05-17, 最終更新日: 2024-01-10)

• 主引用文献: Twarda-Clapa, A.,Krzanik, S.,Kubica, K.,Guzik, K.,Labuzek, B.,Neochoritis, C.G.,Khoury, K.,Kowalska, K.,Czub, M.,Dubin, G.,Domling, A.,Skalniak, L.,Holak, T.A.; 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.; J. Med. Chem., 60:4234-4244, 2017; PubMed: 28482147; DOI: 10.1021/acs.jmedchem.7b00104

実験手法

X-RAY DIFFRACTION (1.85 Å)