5J5R

M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718

Summary for 5J5R

Entry DOI	10.2210/pdb5j5r/pdb
Descriptor	Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, cyclohexyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone, INOSINIC ACID, ... (4 entities in total)
Functional Keywords	inhibitor, impdh, mycobacterium, guab2, oxidoreductase
Biological source	Mycobacterium thermoresistibile ATCC 19527 More
Total number of polymer chains	1
Total formula weight	40590.18
Authors	Pacitto, A.,Ascher, D.B.,Blundell, T.L. (deposition date: 2016-04-03, release date: 2016-10-19, Last modification date: 2024-05-08)
Primary citation	Singh, V.,Donini, S.,Pacitto, A.,Sala, C.,Hartkoorn, R.C.,Dhar, N.,Keri, G.,Ascher, D.B.,Mondesert, G.,Vocat, A.,Lupien, A.,Sommer, R.,Vermet, H.,Lagrange, S.,Buechler, J.,Warner, D.F.,McKinney, J.D.,Pato, J.,Cole, S.T.,Blundell, T.L.,Rizzi, M.,Mizrahi, V. The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis. ACS Infect Dis, 3:5-17, 2017 Cited by PubMed: 27726334 DOI: 10.1021/acsinfecdis.6b00102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation