5J5A

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 70786556)

5J5A の概要

• エントリーDOI: 10.2210/pdb5j5a/pdb
• 分子名称: Methionyl-tRNA synthetase, putative, METHIONINE, [(3S)-3-(1H-benzimidazol-2-yl)piperidin-1-yl](2-methyl-1-benzofuran-5-yl)methanone, ... (4 entities in total)
• 機能のキーワード: synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123170.06

構造登録者

Barros-Alvarez, X.,Koh, C.Y.,Hol, W.G.J. (登録日: 2016-04-01, 公開日: 2017-01-25, 最終更新日: 2024-03-06)

• 主引用文献: Huang, W.,Zhang, Z.,Barros-Alvarez, X.,Koh, C.Y.,Ranade, R.M.,Gillespie, J.R.,Creason, S.A.,Shibata, S.,Verlinde, C.L.,Hol, W.G.,Buckner, F.S.,Fan, E.; Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.; Eur J Med Chem, 124:1081-1092, 2016; PubMed: 27788467; DOI: 10.1016/j.ejmech.2016.10.024

実験手法

X-RAY DIFFRACTION (2.7 Å)