5J58
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1856)
Summary for 5J58
| Entry DOI | 10.2210/pdb5j58/pdb |
| Descriptor | Methionyl-tRNA synthetase, putative, METHIONINE, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
| Biological source | Trypanosoma brucei brucei |
| Total number of polymer chains | 2 |
| Total formula weight | 123732.05 |
| Authors | Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2016-04-01, release date: 2017-01-25, Last modification date: 2024-03-06) |
| Primary citation | Huang, W.,Zhang, Z.,Barros-Alvarez, X.,Koh, C.Y.,Ranade, R.M.,Gillespie, J.R.,Creason, S.A.,Shibata, S.,Verlinde, C.L.,Hol, W.G.,Buckner, F.S.,Fan, E. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124:1081-1092, 2016 Cited by PubMed: 27788467DOI: 10.1016/j.ejmech.2016.10.024 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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