5J4V
The crystal structure of Inhibitor Bound to JCV Helicase
Summary for 5J4V
Entry DOI | 10.2210/pdb5j4v/pdb |
Related | 5J40 5J47 5J4Y |
Descriptor | Large T antigen, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total) |
Functional Keywords | helicase, hexamer, zn, atp, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | JC polyomavirus (JCPyV) |
Cellular location | Host nucleus : P03072 |
Total number of polymer chains | 1 |
Total formula weight | 43051.05 |
Authors | Ter Haar, E. (deposition date: 2016-04-01, release date: 2016-07-20, Last modification date: 2024-03-06) |
Primary citation | Bonafoux, D.,Nanthakumar, S.,Bandarage, U.K.,Memmott, C.,Lowe, D.,Aronov, A.M.,Bhisetti, G.R.,Bonanno, K.C.,Coll, J.,Leeman, J.,Lepre, C.A.,Lu, F.,Perola, E.,Rijnbrand, R.,Taylor, W.P.,Wilson, D.,Zhou, Y.,Zwahlen, J.,Ter Haar, E. Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors. J.Med.Chem., 59:7138-7151, 2016 Cited by PubMed: 27385654DOI: 10.1021/acs.jmedchem.6b00486 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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