5J4H
Structure of humanised RadA-mutant humRadA22F in complex with indole-6-carboxylic acid
Summary for 5J4H
Entry DOI | 10.2210/pdb5j4h/pdb |
Descriptor | DNA repair and recombination protein RadA, 1H-indole-6-carboxylic acid, SODIUM ION, ... (6 entities in total) |
Functional Keywords | dna repair, fragment based drug design, humanisation, hydrolase |
Biological source | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) |
Total number of polymer chains | 1 |
Total formula weight | 25724.24 |
Authors | Fischer, G.,Marsh, M.,Moschetti, T.,Sharpe, T.,Scott, D.,Morgan, M.,Ng, H.,Skidmore, J.,Venkitaraman, A.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2016-04-01, release date: 2016-10-19, Last modification date: 2024-05-01) |
Primary citation | Moschetti, T.,Sharpe, T.,Fischer, G.,Marsh, M.E.,Ng, H.K.,Morgan, M.,Scott, D.E.,Blundell, T.L.,R Venkitaraman, A.,Skidmore, J.,Abell, C.,Hyvonen, M. Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428:4589-4607, 2016 Cited by PubMed: 27725183DOI: 10.1016/j.jmb.2016.10.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.374 Å) |
Structure validation
Download full validation report