5J48
PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP
Summary for 5J48
Entry DOI | 10.2210/pdb5j48/pdb |
Descriptor | cGMP-dependent protein kinase 1, 1,2-ETHANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, ... (6 entities in total) |
Functional Keywords | binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, analogs |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13976 |
Total number of polymer chains | 2 |
Total formula weight | 31531.70 |
Authors | Campbell, J.C.,Sankaran, B.,Kim, C.W. (deposition date: 2016-03-31, release date: 2017-04-12, Last modification date: 2023-09-27) |
Primary citation | Campbell, J.C.,Henning, P.,Franz, E.,Sankaran, B.,Herberg, F.W.,Kim, C. Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12:2388-2398, 2017 Cited by PubMed: 28793191DOI: 10.1021/acschembio.7b00369 PDB entries with the same primary citation |
Experimental method |
Structure validation
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