5J48

PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP

5J48 の概要

• エントリーDOI: 10.2210/pdb5j48/pdb
• 分子名称: cGMP-dependent protein kinase 1, 1,2-ETHANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, ... (6 entities in total)
• 機能のキーワード: binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, analogs
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q13976
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31531.70

構造登録者

Campbell, J.C.,Sankaran, B.,Kim, C.W. (登録日: 2016-03-31, 公開日: 2017-04-12, 最終更新日: 2023-09-27)

• 主引用文献: Campbell, J.C.,Henning, P.,Franz, E.,Sankaran, B.,Herberg, F.W.,Kim, C.; Structural Basis of Analog Specificity in PKG I and II.; ACS Chem. Biol., 12:2388-2398, 2017; PubMed: 28793191; DOI: 10.1021/acschembio.7b00369

実験手法

X-RAY DIFFRACTION (1.49 Å)