5IZR

Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate inhibitor and Terbium Chloride

Summary for 5IZR

Entry DOI	10.2210/pdb5izr/pdb
Related	5IXC 5IZ5
Descriptor	Cytosolic phospholipase A2 delta, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate, TERBIUM(III) ION, ... (4 entities in total)
Functional Keywords	signal transduction, phospholipase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol: Q86XP0
Total number of polymer chains	4
Total formula weight	369538.87
Authors	Wang, H.,Klein, M.G. (deposition date: 2016-03-25, release date: 2016-06-08, Last modification date: 2016-06-22)
Primary citation	Wang, H.,Klein, M.G.,Snell, G.,Lane, W.,Zou, H.,Levin, I.,Li, K.,Sang, B.C. Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition. J.Mol.Biol., 428:2769-2779, 2016 Cited by PubMed: 27220631 DOI: 10.1016/j.jmb.2016.05.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation