5IYZ

Tubulin-MMAE complex

5IYZ の概要

• エントリーDOI: 10.2210/pdb5iyz/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002173
• 分子名称: Tubulin alpha-1B chain, N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: cell cycle, cytoskeleton, tubulin fold, microtubule
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265902.17

構造登録者

Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E. (登録日: 2016-03-24, 公開日: 2016-08-17, 最終更新日: 2024-01-10)

• 主引用文献: Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E.; Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.; Plos One, 11:e0160890-e0160890, 2016; PubMed: 27518442; DOI: 10.1371/journal.pone.0160890

実験手法

X-RAY DIFFRACTION (1.8 Å)