5IX7

Crystal structure of metallo-DNA nanowire with infinite one-dimensional silver array

5IX7 の概要

• エントリーDOI: 10.2210/pdb5ix7/pdb
• 分子名称: DNA (5'-D(*GP*GP*AP*CP*TP*(CBR)P*GP*AP*CP*TP*CP*C)-3'), SILVER ION, POTASSIUM ION, ... (4 entities in total)
• 機能のキーワード: dna, nanowire, x-ray analysis, metallo-base pairs, silver
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4427.67

構造登録者

Kondo, J.,Tada, Y.,Dairaku, T.,Hattori, Y.,Saneyoshi, H.,Ono, A.,Tanaka, Y. (登録日: 2016-03-23, 公開日: 2017-07-05, 最終更新日: 2024-03-20)

主引用文献

Kondo, J.,Tada, Y.,Dairaku, T.,Hattori, Y.,Saneyoshi, H.,Ono, A.,Tanaka, Y.
A metallo-DNA nanowire with uninterrupted one-dimensional silver array
Nat Chem, 9:956-960, 2017

PubMed Abstract: The double-helix structure of DNA, in which complementary strands reversibly hybridize to each other, not only explains how genetic information is stored and replicated, but also has proved very attractive for the development of nanomaterials. The discovery of metal-mediated base pairs has prompted the generation of short metal-DNA hybrid duplexes by a bottom-up approach. Here we describe a metallo-DNA nanowire-whose structure was solved by high-resolution X-ray crystallography-that consists of dodecamer duplexes held together by four different metal-mediated base pairs (the previously observed C-Ag-C, as well as G-Ag-G, G-Ag-C and T-Ag-T) and linked to each other through G overhangs involved in interduplex G-Ag-G. The resulting hybrid nanowires are 2 nm wide with a length of the order of micrometres to millimetres, and hold the silver ions in uninterrupted one-dimensional arrays along the DNA helical axis. The hybrid nanowires are further assembled into three-dimensional lattices by interactions between adenine residues, fully bulged out of the double helix.

PubMed: 28937663
DOI: 10.1038/nchem.2808

実験手法

X-RAY DIFFRACTION (1.398 Å)