5IWD
HCMV DNA polymerase subunit UL44 complex with a small molecule
Summary for 5IWD
Entry DOI | 10.2210/pdb5iwd/pdb |
Related | 1T6L 1YYP 5IXA |
Descriptor | DNA polymerase processivity factor, 5-methylidene-3-(methylsulfanyl)-2-benzothiophen-4(5H)-one (3 entities in total) |
Functional Keywords | covalent inhibitor, hcmv pol accessory subunit, protein-protein interaction, human cytomegalovirus, dna polymerase, processivity factor, replication-replication inhibitor complex, replication/replication inhibitor |
Biological source | Human cytomegalovirus (strain AD169) (HHV-5) |
Total number of polymer chains | 1 |
Total formula weight | 33215.39 |
Authors | Chen, H.,Coen, D.M.,Hogle, J.M.,Filman, D.J. (deposition date: 2016-03-22, release date: 2016-11-30, Last modification date: 2019-12-11) |
Primary citation | Chen, H.,Coseno, M.,Ficarro, S.B.,Mansueto, M.S.,Komazin-Meredith, G.,Boissel, S.,Filman, D.J.,Marto, J.A.,Hogle, J.M.,Coen, D.M. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis, 3:112-118, 2017 Cited by PubMed: 28183184DOI: 10.1021/acsinfecdis.6b00079 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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