5IW8

Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 4 [5-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]

Summary for 5IW8

• Entry DOI: 10.2210/pdb5iw8/pdb
• Related: 3DKI 3FGP
• Descriptor: O-phosphoserine sulfhydrylase, 5-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid, SODIUM ION, ... (5 entities in total)
• Functional Keywords: mycobacterium tuberculosis, cysteine biosynthesis, sulphur metabolism, inhibitor, lyase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 2
• Total formula weight: 70662.21

Authors

Brunner, K.,Schnell, R.,Schneider, G. (deposition date: 2016-03-22, release date: 2016-08-17, Last modification date: 2024-01-10)

• Primary citation: Brunner, K.,Maric, S.,Reshma, R.S.,Almqvist, H.,Seashore-Ludlow, B.,Gustavsson, A.L.,Poyraz, O.,Yogeeswari, P.,Lundback, T.,Vallin, M.,Sriram, D.,Schnell, R.,Schneider, G.; Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.; J.Med.Chem., 59:6848-6859, 2016; PubMed: 27379713; DOI: 10.1021/acs.jmedchem.6b00674

Experimental method

X-RAY DIFFRACTION (2.04 Å)