5IU8

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12f at 2.0A resolution

5IU8 の概要

• エントリーDOI: 10.2210/pdb5iu8/pdb
• 関連するPDBエントリー: 5IU4 5IU7
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, 2-(furan-2-yl)-N~5~-[2-(4-methylpiperazin-1-yl)ethyl][1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine, ... (9 entities in total)
• 機能のキーワード: g-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutationsm, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P29274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57563.94

構造登録者

Segala, E.,Guo, D.,Cheng, R.K.Y.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,Ijzerman, A.P.,Marshall, F.H.,Cooke, R.M. (登録日: 2016-03-17, 公開日: 2016-06-29, 最終更新日: 2024-01-10)

• 主引用文献: Segala, E.,Guo, D.,Cheng, R.K.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,IJzerman, A.P.,Marshall, F.H.,Cooke, R.M.; Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.; J.Med.Chem., 59:6470-6479, 2016; PubMed: 27312113; DOI: 10.1021/acs.jmedchem.6b00653

実験手法

X-RAY DIFFRACTION (2.002 Å)