5IQZ

Crystal structure of N-terminal domain of Human SIRT7

5IQZ の概要

• エントリーDOI: 10.2210/pdb5iqz/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: SIRT7 protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
• 機能のキーワード: sirt7, fusion protein, maltose binding, alpha histone deacetylase sirtuin, sugar binding protein
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49506.05

構造登録者

Thakur, K.G.,Priyanka, A. (登録日: 2016-03-11, 公開日: 2016-07-27, 最終更新日: 2023-11-08)

主引用文献

Priyanka, A.,Solanki, V.,Parkesh, R.,Thakur, K.G.
Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture
Proteins, 84:1558-1563, 2016

PubMed Abstract: Human SIRT7 is an NAD(+) dependent deacetylase, which belongs to sirtuin family of proteins. SIRT7, like other sirtuins has conserved catalytic domain and is flanked by N- and C-terminal domains reported to play vital functional roles. Here, we report the crystal structure of the N-terminal domain of human SIRT7 (SIRT7(NTD) ) at 2.3 Å resolution as MBP-SIRT7(NTD) fusion protein. SIRT7(NTD) adopts three-helical domain architecture and comparative structural analyses suggest similarities to some DNA binding motifs and transcription regulators. We also report here the importance of N- and C-terminal domains in soluble expression of SIRT7. Proteins 2016; 84:1558-1563. © 2016 Wiley Periodicals, Inc.

PubMed: 27287224
DOI: 10.1002/prot.25085

実験手法

X-RAY DIFFRACTION (2.334 Å)