5IOO

Accommodation of massive sequence variation in Nanoarchaeota by the C-type lectin fold

Summary for 5IOO

• Entry DOI: 10.2210/pdb5ioo/pdb
• Descriptor: AvpA, MAGNESIUM ION (3 entities in total)
• Functional Keywords: massive protein diversification, clec fold, archaea, sugar binding protein, unknown function
• Biological source: Nanoarchaeota archaeon JGI OTU-1
• Total number of polymer chains: 2
• Total formula weight: 57503.26

Authors

Handa, S.,Paul, B.,Miller, J.,Valentine, D.,Ghosh, P. (deposition date: 2016-03-08, release date: 2016-11-09, Last modification date: 2024-10-16)

Primary citation

Handa, S.,Paul, B.G.,Miller, J.F.,Valentine, D.L.,Ghosh, P.
Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements.
Bmc Struct.Biol., 16:13-13, 2016

PubMed Abstract: Diversity-generating retroelements (DGRs) provide organisms with a unique means for adaptation to a dynamic environment through massive protein sequence variation. The potential scope of this variation exceeds that of the vertebrate adaptive immune system. DGRs were known to exist only in viruses and bacteria until their recent discovery in archaea belonging to the 'microbial dark matter', specifically in organisms closely related to Nanoarchaeota. However, Nanoarchaeota DGR variable proteins were unassignable to known protein folds and apparently unrelated to characterized DGR variable proteins.

PubMed: 27578274
DOI: 10.1186/s12900-016-0064-6

Experimental method

X-RAY DIFFRACTION (2.521 Å)