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5ION

Solution Structure of Miz-1 Zinc Finger 13

5ION の概要
エントリーDOI10.2210/pdb5ion/pdb
NMR情報BMRB: 30032
分子名称Zinc finger and BTB domain-containing protein 17, ZINC ION (2 entities in total)
機能のキーワードc2h2 zinc finger, miz-1, zbtb17, transcription factor, transcription
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数1
化学式量合計3298.04
構造登録者
Tremblay, C.,Bedard, M.,Lavigne, P. (登録日: 2016-03-08, 公開日: 2016-03-30, 最終更新日: 2024-05-15)
主引用文献Tremblay, C.,Bedard, M.,Bonin, M.A.,Lavigne, P.
Solution structure of the 13th C2H2 Zinc Finger of Miz-1.
Biochem.Biophys.Res.Commun., 473:471-475, 2016
Cited by
PubMed Abstract: Miz-1 is a BTB/POZ transcription factor that contains 13C2H2 Zinc Finger domains (ZF). Miz-1 transactivates and represses the transcription of a myriad of genes involved in many aspects of the biology of the cell. The detailed molecular interactions through which Miz-1 controls transcription, including its specific DNA binding via its ZF domains, remain to be understood and documented. In our effort to shed light into the structural biology of Miz-1, we have undertaken the determination of the structure of all its ZF and the characterization of their interactions with cognate DNA. The structure of ZF 1 to 10 have already been solved and characterized. Here, we present the structure of the synthetic Miz-1 ZF13 determined by 2D (1)H-(1)H NMR.
PubMed: 26972249
DOI: 10.1016/j.bbrc.2016.03.034
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 5ion
検証レポート(詳細版)ダウンロードをダウンロード

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件を2026-02-04に公開中

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