5IOK

Crystal structure of Taf14 YEATS domain in complex with histone H3K9cr

5IOK の概要

• エントリーDOI: 10.2210/pdb5iok/pdb
• 分子名称: Transcription initiation factor TFIID subunit 14, (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• 機能のキーワード: crotonylation, crotonyllysine, epigenetics, reader, histone h3, h3k9cr, transcription
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); 詳細
• 細胞内の位置: Nucleus: P35189
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 17278.72

構造登録者

Andrews, F.H.,Kuateladze, T.G. (登録日: 2016-03-08, 公開日: 2016-04-20, 最終更新日: 2023-11-15)

主引用文献

Andrews, F.H.,Shinsky, S.A.,Shanle, E.K.,Bridgers, J.B.,Gest, A.,Tsun, I.K.,Krajewski, K.,Shi, X.,Strahl, B.D.,Kutateladze, T.G.
The Taf14 YEATS domain is a reader of histone crotonylation.
Nat.Chem.Biol., 12:396-398, 2016

PubMed Abstract: The discovery of new histone modifications is unfolding at startling rates; however, the identification of effectors capable of interpreting these modifications has lagged behind. Here we report the YEATS domain as an effective reader of histone lysine crotonylation, an epigenetic signature associated with active transcription. We show that the Taf14 YEATS domain engages crotonyllysine via a unique π-π-π-stacking mechanism and that other YEATS domains have crotonyllysine-binding activity.

PubMed: 27089029
DOI: 10.1038/nchembio.2065

実験手法

X-RAY DIFFRACTION (2.22 Å)